ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Internal dynamics of the NIST monoclonal antibody
Abstract: Monoclonal antibodies (mAbs) bind very selectively to different antigens and mAbs are used as molecularly engineered pharmaceuticals in modern medicine. Excipients (buffers, salts or other cosolutes) are added to therapeutic mAb products to improve their stability, bioavailability and to achieve higher protein concentrations at low macroscopic viscosity. We suggest performing a QENS experiment on IRIS to study the effects of selected excipients on the molecular dynamics on the time-scale of around 100 ps of a reference mAb in solution. In our QENS experiment we would like to investigate the correlation between fast internal motions and slow collective domain motions that have been measured using high-resolution neutron spin-echo spectroscopy. For that purpose, we would like to apply for 7 days beam on IRIS.
Principal Investigator: Dr Andreas Stadler
Experimenter: Dr Julio Martín Pusterla
Experimenter: Dr Ralf Biehl
Experimenter: Dr Margarita Kruteva
Local Contact: Dr Mona Sarter
Experimenter: Dr Szilard Saringer
DOI: 10.5286/ISIS.E.RB2220009
ISIS Experiment Number: RB2220009
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2220009-1 | IRIS | 09 August 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Andreas Stadler et al; (2024): Internal dynamics of the NIST monoclonal antibody, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220009
Data is released under the CC-BY-4.0 license.
