ISIS Neutron and Muon Source Data Journal

Lipid exchange between high density lipoprotein (HDL) and model phosphatidylcholine membranes: the effect of unsaturation and cyclic species

Abstract: Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related cardiovascular diseases. Impact of the results. We have developed protocols to understand lipid exchange between lipoproteins and model membranes using neutron reflection. We have studied the exchange processes between HDL and saturated lipids as well as a natural extract, in the presence and absence of cholesterol. Surprisingly, the presence of cholesterol has little effect on lipid exchange but the natural extract behaves significantly different than the saturated lipids. Here we plan to clarify whether this effect is due to the presence of unsaturations, the presence of cyclic structures or the complexity of the lipid mixture in the dPC extract.

Principal Investigator: Professor Marité Cárdenas Gómez
Experimenter: Dr Dainius Jakubauskas
Local Contact: Dr Rebecca Welbourn
Experimenter: Miss Sarah Waldie
Experimenter: Dr Selma Maric
Experimenter: Mr Rami Iskif
Local Contact: Dr Maxmilian Skoda
Experimenter: Mr Nico Koenig

DOI: 10.5286/ISIS.E.RB1810104

ISIS Experiment Number: RB1810104

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Marité Cárdenas Gómez et al; (2018): Lipid exchange between high density lipoprotein (HDL) and model phosphatidylcholine membranes: the effect of unsaturation and cyclic species, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810104

Data is released under the CC-BY-4.0 license.