ISIS Neutron and Muon Source Data Journal

Exploring Supramolecular Modulation of Polymyxin-Lipopolysaccharide Interactions

Abstract: Polymyxins remain an indispensable drug to treat life-threatening multi-drug resistant Gram-negative infections. To address the growing global challenge of antibiotic resistance, it is key to optimise the pharmacological profile of these antimicrobial lipopeptides and explore potential drug delivery approaches that enhance their performance. We have developed supramolecular polymyxin-based nanostructures formed either by self-assembly or by polymer co-assembly. In this experiment we want to test how these novel PmB formulations affect the interaction of the antimicrobial with models of the Gram-negative outer membrane, the natural target of these drugs. The proposal joins expertise from two projects, one developing deuterated bacterial model membranes mimicking sensitive and resistant bacteria for antibiotic research and one developing novel antibiotic formulations to tackle the spreading antibiotic resistance

Principal Investigator: Dr Nicolo Paracini
Local Contact: Dr Luke Clifton
Experimenter: Professor håvard jenssen
Experimenter: Professor Martin Malmsten
Experimenter: Professor Reidar Lund
Experimenter: Dr Thomas Daniel Vogelaar
Experimenter: Mr Michael Lyngbæk Christensen

DOI: 10.5286/ISIS.E.RB2610179

ISIS Experiment Number: RB2610179

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Nicolo Paracini et al; (2026): Exploring Supramolecular Modulation of Polymyxin-Lipopolysaccharide Interactions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610179

Data is released under the CC-BY-4.0 license.