ISIS Neutron and Muon Source Data Journal

Contrast-resolved dynamics and conformational entropy of thermo-responsive vesicles by quasi-elastic neutron scattering

Abstract: Self-assembled spherical bilayers (vesicles) serve as essential architectures for targeted drug delivery and micro-reactor technologies. However, their formation is inherently linked to molecular and environmental parameters, such as surfactant architecture, interactions and temperature. Our previous QENS study on a known surfactant vesicle system successfully established a direct correlation between temperature, ionic strength, and the dynamic response of these systems, revealing clear signatures of molecular mobility and structural rearrangement. While these findings demonstrate the importance of these effects, the current dataset remains limited by incomplete contrast variation across all conditions. To achieve a comprehensive, contrast-resolved mechanistic model, we require the proposed measurement series. This will allow us to fully elucidate structural and dynamic contributions of mixed surfactant vesicles.

Principal Investigator: Dr Thomas McCoy
Experimenter: Mr Alberto Centenaro
Local Contact: Dr Mona Sarter
Experimenter: Mr Lassi Tiihonen

DOI: 10.5286/ISIS.E.RB2620795

ISIS Experiment Number: RB2620795

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Thomas McCoy et al; (2026): Contrast-resolved dynamics and conformational entropy of thermo-responsive vesicles by quasi-elastic neutron scattering, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2620795

Data is released under the CC-BY-4.0 license.