ISIS Neutron and Muon Source Data Journal

Application of new experimental gaskets to mimic pharmaceutical tabletting

Abstract: Tablet manufacturing involves compressing powder blends into solid compacts, a process that can induce phase transformations in active pharmaceutical ingredients (APIs), potentially affecting drug performance. This proposal outlines a neutron diffraction study using a novel gasket assembly on the Pearl instrument to simulate pharmaceutical tabletting on neat active pharmaceutical ingredient powders. Hydrochlorothiazide (HCT) is selected as the model compound due to its recoverable high-pressure phase, previously observed under compression and confirmed via electron diffraction and synchrotron studies. The new gasket design mimics tablet press geometry and accommodates larger sample volumes, enabling in-situ structural analysis under both pseudo-hydrostatic and non-hydrostatic conditions. The experiment aims to quantify phase transformation extents across pressure ranges up to 3 GPa, providing critical insights into compression-induced polymorphism and enhancing the relevance of high-pressure crystallography to pharmaceutical applications.

Principal Investigator: Dr Iain Oswald
Local Contact: Dr Craig Bull

DOI: 10.5286/ISIS.E.RB2610166

ISIS Experiment Number: RB2610166

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Iain Oswald et al; (2026): Application of new experimental gaskets to mimic pharmaceutical tabletting, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610166

Data is released under the CC-BY-4.0 license.