ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Investigation of the antimicrobial effects and mechanisms of the A-beta peptide on natural biomimetic membrane models using NR
Abstract: The A-beta peptides, traditionally regarded as purposeless byproducts generated through intramembrane cleavage under pathological conditions, have long been associated with Alzheimer's disease. However, growing evidence suggests that these peptides may instead represent an ancient and highly conserved effector component of the innate immune system, evolved to protect the brain against microbial invasion. According to the antimicrobial protection hypothesis, strongly supported by experimental results, A-beta aggregation could reflect not a random pathological process but a dysregulated innate immune response. In this project, we aim to investigate the antimicrobial properties and mechanisms of A-beta using Neutron Reflectometry on biomimetic membrane models derived from eukaryotic and prokaryotic cell extracts. This research seeks to advance our understanding of the molecular mechanisms linking antimicrobial activity and neurodegeneration in Alzheimer's disease.
Principal Investigator: Dr Pablo Sanchez Puga
Experimenter: Dr Krishna Batchu
Local Contact: Dr Arwel Hughes
Experimenter: Dr Francesco Antonio Aprile
Experimenter: Mr Giacomo Corucci
Experimenter: Dr Giovanna Fragneto
Experimenter: Professor Annalisa Pastore
DOI: 10.5286/ISIS.E.RB2610403
ISIS Experiment Number: RB2610403
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2610403-1 | INTER | 15 October 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Pablo Sanchez Puga et al; (2026): Investigation of the antimicrobial effects and mechanisms of the A-beta peptide on natural biomimetic membrane models using NR, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610403
Data is released under the CC-BY-4.0 license.
