ISIS Neutron and Muon Source Data Journal

Probing the interaction of liposomal delivery systems with model Gram-negative bacterial cell envelopes

Abstract: The proposal is focused on the interaction of different liposome compositions with a model of the outer leaflet of the other membrane (OM) at air/water interface. We have investigated the interaction of 2 types of liposome with the model OM outer leaflet using a combination of Langmuir trough and ellipsometry experiments and more recently neutron reflectivity (RB2520346). This proposal is to request one further day of beam time to perform a few samples to complete the neutron studies performed under RB2520346 in order to be able to publish the data in a high impact factor journal. One sample of DPPC-DOPE-DOTAP liposomes takes 3 h (1 h kinetics + 1 h post kinetics +1 h sample change) d-LPS/h-E.coli polar extracts + h-liposomes in ACMW h-LPS/d-E.coli polar extracts + h-liposomes in ACMW h-LPS/h-E.coli polar extracts + d-d-DPPC-liposomes in ACMW h-LPS/h-E.coli polar extracts + d-d-DOPE-liposomes in ACMW h-LPS/h-E.coli polar extracts + h-liposomes in ACMW (reference)

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Richard Campbell
Experimenter: Dr Sarah Gordon
Experimenter: Dr Yixuan Yan

DOI: 10.5286/ISIS.E.RB2690074

ISIS Experiment Number: RB2690074

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2026): Probing the interaction of liposomal delivery systems with model Gram-negative bacterial cell envelopes , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2690074

Data is released under the CC-BY-4.0 license.