ISIS Neutron and Muon Source Data Journal

Spontaneous mixed-surfactant vesicle self-assembly by contrast variation small-angle scattering under differing temperatures and ionic-strength conditions.

Abstract: Amphiphile self-assembly underpins the formation of soft-matter structures such as micelles, bilayers, and vesicles. Vesicles are of particular interest because their closed bilayer architecture provides an enclosed internal aqueous compartment. This unique geometry makes vesicles attractive for applications involving encapsulation and controlled release such as drug delivery. Previously, we have shown that vesicles can be spontaneously formed from aqueous mixtures of two biocompatible surfactants. These vesicles have diameters smaller than 40 nm and are highly sensitive to external triggers such as salt concentration and temperature. Given these intriguing properties, we seek to further understand how the morphology can be precisely tuned through temperature changes, and sample composition with the goal of optimizing these systems as aqueous drug carriers.

Principal Investigator: Mr Alberto Centenaro
Local Contact: Dr Steven Parnell
Experimenter: Mr Lassi Tiihonen
Experimenter: Dr Thomas McCoy
Experimenter: Mr Lucas Lemsom

DOI: 10.5286/ISIS.E.RB2669001

ISIS Experiment Number: RB2669001

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Mr Alberto Centenaro et al; (2026): Spontaneous mixed-surfactant vesicle self-assembly by contrast variation small-angle scattering under differing temperatures and ionic-strength conditions., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2669001

Data is released under the CC-BY-4.0 license.