ISIS Neutron and Muon Source Data Journal

NEW TARGETS FOR ANTICANCER DRUGS ? IMPACT ON THE DYNAMICS OF HUMAN CANCER CELLS

Abstract: The search for efficient anticancer drugs is prompted by the urgent clinical need to improve the prognosis of oncological patients, cancer being the second cause of death worldwide. This QENS experiment will probe intracellular water dynamics in human liver and lung cells (malignant and healthy), with and without Pt-drugs (DNA-binders and phosphate-clamps), searching for differences between: (i) healthy and malignant systems, to better understand normal-to-cancer transition; (ii) drug-free and drug-exposed cells, to assess the drug´s impact on intraccellular water dynamics (a potential secondary pharmacological target). Coupled to previous results, molecular level information will be achieved on carcinogenesis and the cytotoxic profile of unconventional Pt-drugs ? an innovative way of identifying particular features associated to malignancy and of tackling drug´s pharmacodynamics.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Miss Clara Martins
Experimenter: Miss Jessica Domingues Silva
Experimenter: Dr Victoria Garcia Sakai
Local Contact: Dr Mona Sarter
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Miss Raquel Laginha
Experimenter: Professor Luis Alberto Batista de Carvalho

DOI: 10.5286/ISIS.E.RB2520022

ISIS Experiment Number: RB2520022

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2026): NEW TARGETS FOR ANTICANCER DRUGS ? IMPACT ON THE DYNAMICS OF HUMAN CANCER CELLS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520022

Data is released under the CC-BY-4.0 license.