ISIS Neutron and Muon Source Data Journal

Steady shear Rheo-SANS of Pluronic-Hyaluronic acid micellar polycrystals in the radial and tangential sample projections

Abstract: Pluronics (PLs) are thermo-responsive amphiphilic block copolymers widely used for depot injectable drug delivery. To enhance the mechanical strength, drug release rate, and bioavailability, PLs are often formulated with bio-additives, such as a polysaccharide polyelectrolyte hyaluronic acid (HA). The PL-HA systems form micellar polycrystals at temperatures of interest to their applications. Their rheology indicates complex elastoviscoplastic behaviour, and shear banding at shear rates regularly encountered during their delivery/transport. The aim of this study is to characterize the structural changes at steady shear rates below, within, and beyond their banding regime in the Ti-Couette geometry, along the velocity(1)-vorticity(3), and gradient(2)-3 shear planes, complementary to our earlier 1-2 shear cell-based studies, and understand the overall effect of HA therein. The structure-property relationships thus obtained are essential for the design of optimal pharmaceutical formulations from our PL-HA mixtures.

Principal Investigator: Dr Ramya Koduvayur
Experimenter: Dr Lauren Matthews
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB2610663

ISIS Experiment Number: RB2610663

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Ramya Koduvayur et al; (2026): Steady shear Rheo-SANS of Pluronic-Hyaluronic acid micellar polycrystals in the radial and tangential sample projections, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610663

Data is released under the CC-BY-4.0 license.