ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Studying the interaction of amphiphilic SCNPs with a lipidic bilayer supported in solid-liquid cells using neutron reflectometry
Abstract: Single-chain nanoparticles (SCNPs) are made of a single copolymer chain that folds or collapses into a compact spherical or cylindrical shape. These unique structures offer benefits such as excellent solubility and stability in solution, making them versatile carriers for drug delivery systems. Their small size enables efficient cellular uptake and targeted delivery of therapeutics, thereby reducing off-target effects and enhancing treatment effectiveness. On the other hand, stimuli-responsive materials, which change their conformation in response to external stimuli such as pH, temperature, or light, show potential for precisely controlling drug release kinetics. Therefore, combining SCNPs with responsive polymeric materials holds great promise for developing new therapeutic strategies. In this study, we introduce a stimuli-responsive polymeric system that forms SCNPs in water because of the amphiphilic nature of the copolymer, with morphology changing as temperature increases. In these experiments, we examine how these polymers interact with a biomimetic lipid bilayer and how their morphology changes when the composition is altered or the temperature is increased.
Principal Investigator: Ms Leyre Oria
Experimenter: Dr Laura Cervera Gabalda
Experimenter: Dr Armando Maestro
Experimenter: Mrs Maialen Cabrerizo
Local Contact: Dr Stephen Hall
Experimenter: Ms Miriam Peņa Figueroa
Experimenter: Dr Ester Verde-Sesto
DOI: 10.5286/ISIS.E.RB2610499
ISIS Experiment Number: RB2610499
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2610499-1 | OFFSPEC | 26 May 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Ms Leyre Oria et al; (2026): Studying the interaction of amphiphilic SCNPs with a lipidic bilayer supported in solid-liquid cells using neutron reflectometry, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610499
Data is released under the CC-BY-4.0 license.
