ISIS Neutron and Muon Source Data Journal

Development of Warfarin-Loaded Polyelectrolyte Complex Nanoparticles of Chitosan and ?-PGA

Abstract: Warfarin, a vitamin K antagonist which is mainly used in thrombosis treatment, has a narrow therapeutic window, variable bioavailability, and instability due to pH sensitivity, extensive biodistribution and unpredictable absorption, thus causing strict monitoring1-4. Therefore, a controlled and stable delivery system in a polyelectrolyte complex (PEC) comprising chitosan (CS, biocompatible polycation) and -polyglutamic acid ( -PGA, polypeptide polyanion) is developed to produce stable nanoparticles with balance surface charge, where amine groups (-NH3+) of chitosan interact with carboxylate groups (-COO-) of -PGA to encapsulate warfarin with the polymer matrix5-8, as illustrated in Figure 1. The nanoparticles stability depends on pH, ionic strength, and chitosan : -PGA ratio, making structural characterisation essential. Although PEC-based nanoparticles effectively protect drugs, enhance solubility and enable controlled release, the exact localisation whether entrapped in the core or interacts with the outer layer- and the entrapment efficiency of the system remain unclear8. Therefore, Spin-Echo Small-Angle Neutron Scattering (SESANS) is proposed to be conducted to analyse the chain conformation, interchain distance, and internal nanostructure by exploiting the contrast to confirm intra- and intermolecular interaction within CS/ -PGA-warfarin complex. The PEC droplet data will be analysed using a log-normal sphere model, which represents the PEC system in solution.

Principal Investigator: Dr Fatimah Fatimah
Experimenter: Dr Najet Mahmoudi
Experimenter: Mrs Arum Patriati
Local Contact: Dr Steven Parnell
Experimenter: Mrs Khadijah Zharifah
Experimenter: Professor Arry Yanuar Syahriar

DOI: 10.5286/ISIS.E.RB2610579

ISIS Experiment Number: RB2610579

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Fatimah Fatimah et al; (2026): Development of Warfarin-Loaded Polyelectrolyte Complex Nanoparticles of Chitosan and ?-PGA, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610579

Data is released under the CC-BY-4.0 license.