ISIS Neutron and Muon Source Data Journal

Model Lung Surfactant Self-assembly in Deep Eutectic Solvents

Abstract: Deep Eutectic Solvents (DES) are molecular mixtures similar to ionic liquids, having melting points below room temperature. However instead of being a salt, the mixture contains two molecules with strong H bonding that hinder formation of an ordered crystalline network. DES have low vapour pressure, adjustable polarity, and tunable components which make them interesting as green solvents while being far less toxic than typical ionic liquids. They have also been demonstrated to both support self-assembly and preserve structures of biological species such as lipid membranes and proteins in the absence of water. This leads to them having a preservative effect for biomolecules, which we are exploring as a possible way to improve the shelf life of lung surfactant formulations. Here, therefore we wish to study the bulk solution self-assembly of model lung surfactant systems (mixtures of lipids DOPC, DPPC, POPG) to determine how they interact with DES and the morphologies of the aggregates formed by these lipids in these novel solvents.

Principal Investigator: Professor Karen Edler
Experimenter: Mr Ronak Kakadiya
Experimenter: Dr Glenn Coope
Experimenter: Dr Thomas Arnold
Local Contact: Dr Leide Cavalcanti

DOI: 10.5286/ISIS.E.RB2610568

ISIS Experiment Number: RB2610568

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Karen Edler et al; (2026): Model Lung Surfactant Self-assembly in Deep Eutectic Solvents, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610568

Data is released under the CC-BY-4.0 license.