ISIS Neutron and Muon Source Data Journal

METALLODRUG ENCAPSULATION FOR IMPROVED DRUG DELIVERY PROBED BY SMALL ANGLE NEUTRON SCATTERING

Abstract: SANS will be applied for evaluating the effect of anticancer metallodrugs on the structural characteristics of lipid mutilamellar vesicles (MLVs), upon drug encapsulation. The main goal of this study is to attain a detailed understanding of the drug-lipid interactions within multillamelar vesicles, for cisplatin and two new Pt- and Pd-agents, aiming at a controlled drug delivery that will allow an improved therapeutic efficiency coupled to lower deleterious side effects an minimised acquired resistance. This is an innovative way of tackling drug s interplay with lipid MLVs and drug delivery, for an improved chemotherapeutic activity and better patient prognosis. The study builds on successful experiments previously performed for these systems at ISIS (INS and QENS) and Diamond (FTIR).

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Mona Sarter
Experimenter: Professor Luis Alberto Batista de Carvalho
Local Contact: Dr Leide Cavalcanti
Experimenter: Mr João Santos

DOI: 10.5286/ISIS.E.RB2610108

ISIS Experiment Number: RB2610108

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2026): METALLODRUG ENCAPSULATION FOR IMPROVED DRUG DELIVERY PROBED BY SMALL ANGLE NEUTRON SCATTERING, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610108

Data is released under the CC-BY-4.0 license.