ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Complexation of ultra-hydrophobic sex hormones in deuterated cyclodextrin for medical applications
Abstract: U-RHYTHM is a groundbreaking wearable diagnostic clinical research device at the Bristol Medical School that uses micro-dialysis to sample hormones directly from human interstitial fluid at closely-space intervals throughout the day and night, monitoring the dynamics of hundreds of metabolites and advancing the field of endocrinology. However, ultra-hydrophobic sex hormones currently cannot be detected due to their low concentrations and their adsorption to the device tubing. Our previous studies explored the use triblock copolymer Pluronic F127 to increase hormone solubility and protect them from adsorption. Here, we propose a study to investigate the nanoscale structure and behaviour of cyclodextrin-hormone complexes using deuterated cyclodextrin, as a new method for the protection, separation and detection of the sex hormones. This study will provide insights into how hormones with different molecular architecture interact with d-CD at varying molar ratios and concentrations, ultimately achieving enhanced clinical capacity of the U-RHYTHM technology
Principal Investigator: Professor Wuge Briscoe
Experimenter: Miss Elena Venturelli
Local Contact: Dr Lauren Matthews
Experimenter: Dr Najet Mahmoudi
Experimenter: Miss Jia He
Experimenter: Mr Bozhidar Zhelev
Experimenter: Miss Chenlin Lu
DOI: 10.5286/ISIS.E.RB2520669
ISIS Experiment Number: RB2520669
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2520669-1 | SANS2D | 14 May 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Wuge Briscoe et al; (2026): Complexation of ultra-hydrophobic sex hormones in deuterated cyclodextrin for medical applications, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520669
Data is released under the CC-BY-4.0 license.
