ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Understanding the dynamics of Beta-lactam antibiotic resistance using neutrons
Abstract: The most important mechanism of resistance to the clinically vital beta-lactam antibiotics involves their degradation by beta-lactamase catalysed hydrolysis. Beta-Lactamase inhibitors (BLI) have been developed and studied in detail by crystallography. There is however a poor understanding of how BLIs affect the dynamics of beta-lactamases, including mutants that are resistant to BLIs, but which do not have a clear effect on classical kinetics. We propose to address this knowledge gap by collaborative work employing neutron scattering studies on already available beta-lactamases and mechanistically different types of established and new BLIs.
Principal Investigator: Professor Christopher Schofield
Experimenter: Professor Fernanda Duarte Gonzalez
Local Contact: Dr Mona Sarter
Experimenter: Dr Liam Wilson
DOI: 10.5286/ISIS.E.RB2610589
ISIS Experiment Number: RB2610589
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2610589-1 | IRIS | 24 February 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Christopher Schofield et al; (2026): Understanding the dynamics of Beta-lactam antibiotic resistance using neutrons , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2610589
Data is released under the CC-BY-4.0 license.
