ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Uncovering the solution structure of habit related polymorphic amino acid - DL-methionine
Abstract: Understanding crystal structure during the crystallisation process is of paramount importance for uncovering self-assembly mechanisms and kinetics. The link between polymorph, habit and crystallisation conditions is still not fully understood but is necessary for the optimisation of physicochemical properties such as dissolution rate of pharmaceuticals. We have uncovered a non-linear relationship between anti-solvent ratio and polymorphic / habit expression in the cooling crystallisation of the essential amino acid DL-methionine, in contrast to a previous study on this material. Using neutron diffraction we will interrogate the liquid structure before crystallisation occurs to see how the differences in anti-solvent fraction are influencing the final polymorphic and habit (shape) form. This will then be compared to in situ diffraction studies at Diamond Light Source investigating detailed single crystal XRD with simultaneous 3D habit analysis in a custom flow crystallisation apparatus.
Principal Investigator: Dr Karen Robertson
Experimenter: Dr Haresh Manyar
Experimenter: Dr Anuradha Pallipurath Radhakrishnan
Experimenter: Dr Daniel Bowron
Local Contact: Dr Terri-Louise Hughes
Experimenter: Miss Scarlett Abrams
Experimenter: Mr Theodore Dexter Lunny
Experimenter: Ms Gayathri Manoj
Experimenter: Miss Patcharaporn Inrirai
DOI: 10.5286/ISIS.E.RB2520559
ISIS Experiment Number: RB2520559
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2520559-1 | SANDALS | 27 March 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Karen Robertson et al; (2026): Uncovering the solution structure of habit related polymorphic amino acid - DL-methionine, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520559
Data is released under the CC-BY-4.0 license.
