ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Polycations for gene delivery: deepening their behaviour at cell surface
Abstract: Polycations can efficiently condense plasmid DNA (pDNA) to safely reach target cells without activating the immune system. However, the role of polycations structure on the interaction with cells membranes and toxicity of polyplexes remain unclear. The aim of our work is to develop and optimize innovative formluations of polycations with different architectures (linear and 3-4 arms star), condensated with DNA. To ptimixe their efficiency with cell-free strategies, we aim at understanding the molecular details of different nanovectors interaction with complex biomimetic membranes. Not only the interaction at cell surface will be mimed, but also the interaction once in endosomal environment.
Principal Investigator: Dr Valeria Rondelli
Experimenter: Ms Maria Giovanna De Pasquale
Experimenter: Dr Anastasiia Murmiliuk
Experimenter: Ms Maria Giovanna De Pasquale
Local Contact: Dr Stephen Hall
Experimenter: Dr Alexandros Koutsioumpas
DOI: 10.5286/ISIS.E.RB2520208
ISIS Experiment Number: RB2520208
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2520208-1 | OFFSPEC | 11 March 2029 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Valeria Rondelli et al; (2026): Polycations for gene delivery: deepening their behaviour at cell surface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520208
Data is released under the CC-BY-4.0 license.
