ISIS Neutron and Muon Source Data Journal

Probing interactions between sponge phase lipid nanoparticles and supported lipid bilayers

Abstract: Non-lamellar lipid nanoparticles (LNPs) are a promising line of inquiry for future drug delivery, where lipid sponge phase are particularly in particular for larger molecules like enzymes and other functional proteins. Here myoglobin (Mb), a functional protein relevant in the context of developing iron supplements is studied. We started investigating the potential interaction between our optimised LNPs and lipid bilayers mimicking the cell membrane. During a recent experiment on POLREF RB no. 2420477, we used polarized neutron reflectometry (PNR) and lipid bilayer deposited on silica caped magnetic reference layers to explore the interaction between supported lipid bilayers, composed of POPC and the DOPC/GMO-50 LNPs We now propose exploring more complex bio-mimicking membranes that closely match in vivo systems should be studied. These studies will help to uncover LNP interaction for drug delivery.

Principal Investigator: Professor Tommy Axel Nylander
Local Contact: Dr Andrew Caruana
Experimenter: Mr Marshall Machingauta
Experimenter: Dr Alessandra Luchini
Experimenter: Dr Edward Stuckey
Experimenter: Miss Anna Stephens
Experimenter: Ms Thea Maria Kerstin Kristersdotter

DOI: 10.5286/ISIS.E.RB2520482

ISIS Experiment Number: RB2520482

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Tommy Axel Nylander et al; (2026): Probing interactions between sponge phase lipid nanoparticles and supported lipid bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520482

Data is released under the CC-BY-4.0 license.