ISIS Neutron and Muon Source Data Journal

Neutron Reflectometry investigation of organo-rhodium complexes in model membranes.

Abstract: Half-sandwich penta- and tetra-methylcyclopentadienyl (Cp*, CpxPh, CpxPhPh) Rh(III) complexes [(?5-Cp*)Rh(N,N?)Cl]+ (N,N = (4-R2-phenyl-azopyridine-5-R1)Cl]PF6, R2 = CF3/Br/H R1 = OH/NMe2 ) show potent anticancer activity against tumour cells, including, lung cancer. Our previous work using 3D cryo-imaging suggested the accumulation of these compounds in lipid membranes, which would be a novel activity pathway. DFT calculations support this finding revealing the complexes interacts with the lipid tails. We propose to use Neutron Reflectometry to study the interaction of these complexes with model membranes to experimentally and structurally resolve the interaction of these novel anti-cancer compounds with cellular membranes. From NR studies we expect to resolve the position of the complex relative to the model membrane and the mechanism of interaction. Additionally we will resolve changes in the membrane lipid distribution to elucidate any membrane perturbing effects of these compounds. This will provide valuable information on the activity of these novel drugs.

Principal Investigator: Dr Edward Lant
Local Contact: Dr Luke Clifton
Experimenter: Dr Jeff Armstrong
Experimenter: Professor Peter Sadler

DOI: 10.5286/ISIS.E.RB2520067

ISIS Experiment Number: RB2520067

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Edward Lant et al; (2025): Neutron Reflectometry investigation of organo-rhodium complexes in model membranes. , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520067

Data is released under the CC-BY-4.0 license.