ISIS Neutron and Muon Source Data Journal

Probing the interaction of lipid nanosystems as drug carriers for eye pathologies with simulated corneal membranes

Abstract: The development of effective and targeted drug delivery systems for therapeutics and diagnostics is a challenging matter. Lipid-based nanocarriers are emerging as optimal candidates to achieve enhanced control over drug release, target selectivity and biocompatibility, thus resulting in improved pharmacokinetic profiles. The fabrication of these systems through precision microfluidics allows to obtain optimized composition, structure and surface properties with high reproducibility, by screening a large number of synthetic parameters through experimental design approaches. In this work, we synthetized optimized transethosomes as vectors for treatment of eye pathologies by screening varied lipid components and polymer coatings. The fundamental understanding of the mechanism of nanosystems interaction with membranes is essential to achieve control over intracellular drug release, correlating structural and dynamic properties to carrier functionality, thus obtaining suitable prototypes for clinical applications.

Principal Investigator: Dr Ilaria Clemente
Local Contact: Dr Stephen Hall
Experimenter: Miss Giulia Gabbricci
Experimenter: Dr Luigi Talarico

DOI: 10.5286/ISIS.E.RB2520484

ISIS Experiment Number: RB2520484

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Ilaria Clemente et al; (2025): Probing the interaction of lipid nanosystems as drug carriers for eye pathologies with simulated corneal membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520484

Data is released under the CC-BY-4.0 license.