ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Quasi Elastic Neutron Scattering Investigations on Gamma Irradiated Hybrid Cellulose Membrane for Uremic Toxin Removal
Abstract: The efficiency of hemodialysis membranes in removing small uremic toxins, such as urea and creatinine, remains a critical challenge for the treatment of end-stage renal disease (ESRD). To address this issue, we propose a hybrid membrane system composed of cellulose acetate (CA) integrated with mesoporous silica (MS) and surface-modified with poly(ethylene glycol) methyl ether (PEGMEA). This design aims to enhance membrane performance by utilizing the biocompatibility and semi-permeability of CA, the adsorptive capacity of MS, and the hydrophilic, antifouling properties provided by PEGMEA grafting via gamma irradiation at 5 kGy. Structural and morphological characterizations have identified a promising membrane variant, i.e. CA-PEGMEA (5 kGy) hybridized with MS, for further investigation. To gain insight into the molecular-level diffusion of urea, a predominant uremic toxin, we will employ Quasi-Elastic Neutron Scattering (QENS) at physiological temperature (37°C). This study will assess urea dynamics within the hybrid membrane and its individual components, contributing to a deeper understanding of the transport mechanisms critical to dialysis efficacy.
Principal Investigator: Mrs Arum Patriati
Experimenter: Professor Arry Yanuat Syahriar
Local Contact: Dr Mona Sarter
Experimenter: Dr Indri Badria Adilina
Experimenter: Ms Muflikhah Muflikhah
Experimenter: Professor Stewart Parker
Experimenter: Dr Meri Suhartini
DOI: 10.5286/ISIS.E.RB2520316
ISIS Experiment Number: RB2520316
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2520316-1 | IRIS | 17 September 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Mrs Arum Patriati et al; (2025): Quasi Elastic Neutron Scattering Investigations on Gamma Irradiated Hybrid Cellulose Membrane for Uremic Toxin Removal , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2520316
Data is released under the CC-BY-4.0 license.
