ISIS Neutron and Muon Source Data Journal

Experimental measurements of the bulk modulus of cubosome using SANS with contrast variation

Abstract: Cubosomes are dispersions of the inverse bicontinuous cubic phase that have attracted significant attention in the context of drug delivery due to their peculiar features. To optimise their formulation the softness of the individual drug carrier has to be finely tuned since it affects the uptake of a colloidal particle within membranes. We will apply a methods based on SANS with contrast variation to determine the bulk modulus of cubosomes obtained using twi different lipids, monoolein (GMO) or phytantriol (PHYT), and stabilised by two different poloxamers, namely Pluronic F127 and F108. The data will be analysed using both the Guinier's analysis, the fitting of the determined form factors by analytical models, and using computer simulations. From this analysis, we will determine the variation of the cubosomes size as a function of the applied osmotic pressure exerted by a deuterated polymer contrast matched in D2O.

Principal Investigator: Dr Marco Fornasier
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Andrea Scotti
Local Contact: Dr Lauren Matthews
Experimenter: Dr Judith Houston
Experimenter: Dr Ariane Fournier

DOI: 10.5286/ISIS.E.RB2510150

ISIS Experiment Number: RB2510150

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Marco Fornasier et al; (2025): Experimental measurements of the bulk modulus of cubosome using SANS with contrast variation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510150

Data is released under the CC-BY-4.0 license.