ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Architecture of Sulfonate Polymer Brushes and their Complex with BMP-2
Abstract: Bone morphogenetic proteins (BMPs) play an important role in tissue repair, making their incorporation into biomaterials scaffolds an important scientific challenge. Heparin facilitates BMP capture and retention but suffers from instability. Our recent study suggests biomimetic poly(sulfopropyl methacrylate) (PSPMA) and poly(styrene sulfonate) (PSS) brushes as stable BMP anchors. Characterisation via surface plasmon resonance and quartz crystal microbalance showed PSPMA's strong affinity for BMP2, impacting matrix deposition by fibroblasts. However, the brush morphology influences the BMP adsorption. Neutron reflectometry is the most sensitive charaterisation methodology to provide insights into PSPMA and PSS brush morphology, and BMP2 adsorption mechanisms, guiding scaffold engineering for regenerative medicine.
Principal Investigator: Dr Ali Zarbakhsh
Local Contact: Dr Mario Campana
Experimenter: Professor Julien Gautrot
DOI: 10.5286/ISIS.E.RB2420042
ISIS Experiment Number: RB2420042
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2420042-1 | OFFSPEC | 09 May 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Ali Zarbakhsh et al; (2025): Architecture of Sulfonate Polymer Brushes and their Complex with BMP-2, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420042
Data is released under the CC-BY-4.0 license.
