ISIS Neutron and Muon Source Data Journal

Radiobiological measurements with epithermal neutrons for Boron Neutron Capture Therapy treatment planning

Abstract: Boron neutron capture therapy (BNCT) is an experimental form of radiotherapy based on the combined effect of the uptake of a 10B-containing compound and the irradiation with low-energy neutrons. This therapy is currently expanding widely by means of compact accelerator neutron sources that can be installed in hospitals. These new facilities will produce epithermal beams for the therapy. This energy range is required to allow neutrons to penetrate the body and reach the tumour once thermalized. The relative biological effectiveness (a key factor for treatment planning) of neutrons in this energy range is not well known, and it is currently extrapolated from thermal or fast neutrons. The measurements proposed in this project pursue obtaining radiobiological data for both tumour and normal cells using epithermal neutrons and compare to the results of studies using other neutron energy ranges at other facilities.

Principal Investigator: Professor Jose Ignacio Porras Sanchez
Experimenter: Dr Ludmila Mee
Local Contact: Dr Matthew Krzystyniak
Experimenter: Ms Cristina Méndez Malagón
Experimenter: Professor Maria Jose Ruiz Magaña
Experimenter: Dr María Carmen Ruiz Ruiz

DOI: 10.5286/ISIS.E.RB2510233

ISIS Experiment Number: RB2510233

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jose Ignacio Porras Sanchez et al; (2025): Radiobiological measurements with epithermal neutrons for Boron Neutron Capture Therapy treatment planning , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510233

Data is released under the CC-BY-4.0 license.