ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Connecting cellular water behaviour to drug action
Abstract: Considering that the dynamical window covered by IRIS (or OSIRIS) is within the observed diffusion coefficient range for intracellular water, this proposal aims to achieve a much better understanding of the behaviour of cellular water before and after being treated by the monoclonal antibody tocilizumab (TCZ); either free of, or encapsulated in, a newly developed biopolymeric nanoparticle. It is expected that cells treated with free or encapsulated TCZ, as opposed to cells treated only with the NPs, will present a different flexibility when compared to untreated cells (control).
Principal Investigator: Dr Fabio Formiga
Experimenter: Dr Douglas Dourado
Experimenter: Mrs Paloma Marques da Silva
Experimenter: Dr Jose Enedilton Medeiros Pereira
Local Contact: Dr Mark Telling
Experimenter: Professor Heloisa Nunes Bordallo
Experimenter: Mr Unique Gyanu Yogi
Experimenter: Mr Lukas Machuca-Beier
Experimenter: Mr Charalampos Tsekeridis
DOI: 10.5286/ISIS.E.RB2510167
ISIS Experiment Number: RB2510167
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2510167-1 | IRIS | 12 May 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Fabio Formiga et al; (2025): Connecting cellular water behaviour to drug action , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510167
Data is released under the CC-BY-4.0 license.
