ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Saponin-lipid nanoparticles and their formulation intermediates: From molecular distribution to supramolecular structure
Abstract: Saponins are a large family of glycoconjugates that share a triterpene structure. When formulated together with phospholipids and cholesterol, they self-assemble into a variety of unique structures depending on the composition. The Matrix-M? adjuvant consists of two different populations of physically stable nanoparticles based on two different saponin fractions, and has been successfully applied in the clinic in e.g. vaccines against Covid, malaria and veterinary vaccines. Their spherical cage-like structures and structural features have been previously characterised using lab-based methods and SAXS. However, little is understood about the molecular distribution within the saponin-lipid nanoparticles. We have recently successfully studied these particles using SANS. We now propose further characterization of the temperature related stability and the changes in morphology that the particles undergo during formulation. Knowledge of temperature effects and the self-assembly process will contribute to the scientific understanding of how these complex particles are formed which is essential information for product development.
Principal Investigator: Dr Margaret Holme
Local Contact: Dr James Doutch
Experimenter: Dr Per John Wessman
Experimenter: Dr Alexander Idström
Experimenter: Dr Marie-Madeleine Walz
Experimenter: Dr Linda Alskär
Experimenter: Ms Johanna Fredriksson
DOI: 10.5286/ISIS.E.RB2510492
ISIS Experiment Number: RB2510492
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2510492-1 | ZOOM | 22 May 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Margaret Holme et al; (2025): Saponin-lipid nanoparticles and their formulation intermediates: From molecular distribution to supramolecular structure, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510492
Data is released under the CC-BY-4.0 license.
