ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Characterization of Antimicrobial Peptide Distribution and Nano-Scale Structures in HEC Hydrogels using SANS
Abstract: Studying the structural mechanisms of antimicrobial peptides (AMPs) in enhancing the mechanical properties of hydrogels is essential for developing effective drug delivery systems. Hydroxyethyl cellulose (HEC)-based hydrogels are promising in biomedical applications due to their biocompatibility, water retention, and tunable mechanical properties. A significant focus is on the encapsulation and controlled release of AMPs, crucial for combating drug-resistant bacteria in applications like wound dressings. However, challenges persist in ensuring peptide stability and controlled release. Small-angle neutron scattering (SANS) offers a powerful, non-destructive method to investigate the internal nanostructure of hydrogels, providing insights into the spatial distribution of embedded molecules like AMPs. This study aims to utilize SANS to explore how the structural organization of HEC hydrogels influences AMP distribution and release profiles, ultimately affecting their therapeutic efficacy in drug delivery.
Principal Investigator: Professor Jian Lu
Experimenter: Mr kangcheng shen
Experimenter: Miss Caroline Ding
Experimenter: Mr Shilin Deng
Experimenter: Miss Yingyu Wang
Local Contact: Dr Lauren Matthews
Experimenter: Dr Mingrui Liao
Experimenter: Mr Zeyuan ZHUANG
DOI: 10.5286/ISIS.E.RB2510644
ISIS Experiment Number: RB2510644
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2510644-1 | SANS2D | 21 March 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2025): Characterization of Antimicrobial Peptide Distribution and Nano-Scale Structures in HEC Hydrogels using SANS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510644
Data is released under the CC-BY-4.0 license.
