ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Temperature Effects upon Monoclonal Antibody Adsorption at PDMS/Water Interface Studied by Neutron Reflection
Abstract: In our previous studies, we have dynamically traced the adsorption of a mAb coded as COE-3 upon different temperatures using Spectroscopic Ellipsometer (SE). However, SE cannot tell us the detailed nanostructure of the adsorbed COE-3 layer. Neutron Reflection is about the only technique that can reveal the finer structure of the adsorbed layer. When combined with deuterium labelling, the orientation of COE-3 as long as its vertical arrangement at varied temperatures can be readily revealed. This study thus can give us the insight view of how protein drugs response to temperature change.
Principal Investigator: Professor Jian Lu
Experimenter: Mr kangcheng shen
Local Contact: Dr John Webster
Experimenter: Mr Shilin Deng
Experimenter: Dr Mingrui Liao
DOI: 10.5286/ISIS.E.RB2420388
ISIS Experiment Number: RB2420388
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2420388-1 | INTER | 11 March 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2025): Temperature Effects upon Monoclonal Antibody Adsorption at PDMS/Water Interface Studied by Neutron Reflection, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420388
Data is released under the CC-BY-4.0 license.
