ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Enzyme Immobilization via Complex Coacervation with Polyampholytes
Abstract: Complex coacervation is a liquid-liquid phase separation that is driven by non-covalent interactions and entropy gain as a result of counterion release. Coacervation is considered as the basis of membraneless organelles, and is used in various industrial applications. Our goal is to use coacervation for enzyme immobilization to maintain or enhance enzyme activity. Considering that biologically-origined macromolecules will have a higher range of application areas in medicine, we have chosen to work on coacervation of hyaluronic-acid derived polyampholytes with lysozyme. SANS measurements coupled with contrast matching will allow us to understand the structure of their coacervates, including the respective distribution of the enzymes and polyampholytes in the coacervate.
Principal Investigator: Professor Ayse Basak Kayitmazer Buyukokutan
Local Contact: Dr James Doutch
Experimenter: Miss Sezin Mamasoglu
DOI: 10.5286/ISIS.E.RB2510495
ISIS Experiment Number: RB2510495
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2510495-1 | ZOOM | 28 March 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Ayse Basak Kayitmazer Buyukokutan et al; (2025): Enzyme Immobilization via Complex Coacervation with Polyampholytes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510495
Data is released under the CC-BY-4.0 license.
