ISIS Neutron and Muon Source Data Journal

Rationally Designed Cationic Peptides Effect on Mimicry Bilayer of Bacteria Membrane

Abstract: This NR experiment proposes to determine how a group of membrane-permeating peptides interact with the lipid bilayer mimicking bacterial membranes. The peptides were designed by mimicking the disordered region of a Dengue viral capsid protein. As this is the first NR study, we request 3 days of INTER time to examine how the native and designed peptides bind to the model bilayer that mimics bacterial membranes with different charges and that also allows us to compare with the outer membrane of human red blood cells with different structures and charges. This study has the potential to offer valuable insights into the impact of peptide sequences on membrane disruptions in future NR experiments.

Principal Investigator: Miss Yingyu Wang
Experimenter: Professor Jian Lu
Local Contact: Dr Arwel Hughes
Experimenter: Miss Tianhao Ge
Experimenter: Mr Zeyuan ZHUANG
Experimenter: Mr Shilin Deng
Experimenter: Dr Mingrui Liao

DOI: 10.5286/ISIS.E.RB2420411

ISIS Experiment Number: RB2420411

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Miss Yingyu Wang et al; (2025): Rationally Designed Cationic Peptides Effect on Mimicry Bilayer of Bacteria Membrane, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420411

Data is released under the CC-BY-4.0 license.