ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Nanoscale features of hydrophilic electrospun fibers
Abstract: The solubility and bioavailability of active pharmaceutical ingredients (APIs) are closely tied to their physical form, with over 75% of emerging APIs facing low aqueous solubility, hindering clinical application. Amorphous solid dispersions (ASDs) offer a promising solution by dispersing APIs in water-miscible polymer carriers, enhancing solubility and dissolution rates. However, ASDs often exhibit storage stability challenges, as they require concentrations above the solubility limit, making them thermodynamically unstable and prone to recrystallization. Electrospinning is an effective technique for producing high-surface-area ASD fibers, which could improve therapeutic delivery, yet the crystallization pathways remains from these systems poorly understood. We intend to probe the nanostructure of drug domains within electrospun fibres using Small-Angle Neutron Scattering (SANS), overcoming limitations of X-ray diffraction in detecting small crystallites. Initial SANS experiments have focused on hydrophobic polymers like poly(caprolactone) and poly(lactide-co-glycolide) with poorly soluble drugs, but exploring hydrophilic materials is essential for rapid drug release in applications like orally-dispersible medicines. This SANS proposal will thus probe nanoscale features of these hydrophilic electrospun ASDs.
Principal Investigator: Dr Michael Cook
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Abhishek Rajbanshi
Experimenter: Professor Gareth Williams
Experimenter: Miss Luyao Wang
DOI: 10.5286/ISIS.E.RB2510524
ISIS Experiment Number: RB2510524
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2510524-1 | SANS2D | 02 March 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Michael Cook et al; (2025): Nanoscale features of hydrophilic electrospun fibers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2510524
Data is released under the CC-BY-4.0 license.
