ISIS Neutron and Muon Source Data Journal

How do lipids regulate cell death? Investigating how membrane lipid composition impacts the distribution of lipid-protein complexes formed during apoptosis

Abstract: Apoptosis is a programmed suicide mechanism of cell death that is essential for the removal of dysfunctional cells. Whilst two proteins regulate cell death, the lipid composition of the mitochondrial outer membrane (MOM) is critical to maintaining the balance of their activities. We know that membrane perforation by the apoptotic membrane protein Bax is sensitive to lipid oxidation and concentration of the mitochondrial lipid cardiolipin (CL), but what is the influence of the other lipids in the MOM? The purpose of this proposed experiment is to elucidate the role of other mitochondrial lipids in the Bax-MOM interaction, specifically non-lamellar forming lipids such as PE.

Principal Investigator: Dr Sophie Ayscough
Local Contact: Dr Luke Clifton
Experimenter: Dr Jörgen Ådén
Experimenter: Professor Gerhard Groebner
Experimenter: Dr Hanna Wacklin-Knecht

DOI: 10.5286/ISIS.E.RB2420459

ISIS Experiment Number: RB2420459

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Sophie Ayscough et al; (2025): How do lipids regulate cell death? Investigating how membrane lipid composition impacts the distribution of lipid-protein complexes formed during apoptosis , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420459

Data is released under the CC-BY-4.0 license.