ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
SANS characterization of Melanosomes-derived hybrid particles designed for RNA delivery
Abstract: Melanosomes are cell-secreted vesicles carrying melanin to keratinocytes. Being inherently designed to target skin cells, they are interesting candidates for the development of melanosomes-based nanovectors for the treatment of skin-related diseases, such as psoriasis, skin cancer and genetic skin diseases. In this framework, we are recently working on melanosome-derived vesicles, which have shown promising ability to transfect RNA to keratinocytes. With this SANS proposal we aim at (i) improving the structural and physicochemical characterization of these hybrid systems, (ii) structurally characterize RNA binding ability of melanosomes-based vectors (iii) determine the mechanism of interaction of melanosomes-derived hybrid vesicles with bio-relevant interfaces, i.e., lipid vesicles mimicking the composition of keratinocytes. Overall, the results of the study will contribute at improving the fundamental knowledge on melanosomes, thus fostering their application in RNA delivery and, more in general in the biomedical field.
Principal Investigator: Dr Costanza Montis
Experimenter: Dr Christopher Morris
Experimenter: Miss Yang Yajie
Local Contact: Dr Najet Mahmoudi
Experimenter: Professor Debora Berti
Experimenter: Ms Valentina Pacciani
Experimenter: Dr Lucrezia Caselli
Experimenter: Dr Arianna Balestri
Experimenter: Miss Deborah Bonavolontà
Experimenter: Miss Xinyun Qiu
DOI: 10.5286/ISIS.E.RB2420288
ISIS Experiment Number: RB2420288
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2420288-1 | SANS2D | 13 March 2028 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Costanza Montis et al; (2025): SANS characterization of Melanosomes-derived hybrid particles designed for RNA delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420288
Data is released under the CC-BY-4.0 license.
