ISIS Neutron and Muon Source Data Journal

A Fully Asymmetric Protein-Containing Gram-Negative bacterial Outer membrane Model

Abstract: Due to antimicrobial resistance, bacterial infections, specifically those due to Gram-negative (GN) bacteria, represent a serious danger to human health. To combat infections by these pathogens, there is an urgent need to develop new antibiotics. The GN bacterial outer membrane (OM), with its unique architecture provides bacteria with additional protection against many antibiotics and has long been a target for the few remaining broad-spectrum antibiotics. Model membranes are a valuable tool for gaining a deeper understanding of the behaviour of the GN OM, and when combined with powerful characterisation techniques such as neutron reflectometry can been used to provide precise complex structural information into the mechanisms of action of new and existing antibiotics. Herein we propose to continue developing a novel route to obtain fully asymmetric, protein containing OM model systems. As such we will develop one of the most physiologically relevant models of the GN OM currently available.

Local Contact: Dr Luke Clifton
Experimenter: Miss Corrin Blake

DOI: 10.5286/ISIS.E.RB2420112

ISIS Experiment Number: RB2420112

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Luke Clifton et al; (2025): A Fully Asymmetric Protein-Containing Gram-Negative bacterial Outer membrane Model, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420112

Data is released under the CC-BY-4.0 license.