ISIS Neutron and Muon Source Data Journal

Self-assembled polyrotaxane hydrogels based on dynamic disulfide bonds

Abstract: We have developed novel hydrogels with remarkable toughness and stretchability through the threading and host-guest interactions between thiolated ?-cyclodextrins (SH?CD) and poly(ethyleneglycol) (PEG) (PhD project of Xiang Xu). The formation of disulfide bridges between SH?CD threaded on different chains leads to the formation of a network. Properties can be improved with the addition of thiols as PEG end groups, preventing the unthreading of SH?CD from the chains. The design of these gels, with crosslinks able to slide and rotate, and disulfide bonds, which present a range of attractive properties, from in vivo degradation, to mucoadhesion, or cell permeation enhancement, make these gels excellent candidates for biomedical applications. We request rapid access to enable timely publication and because access through the direct route will result in beamtime too close to the end of Xiang?s PhD.

Principal Investigator: Dr Cecile Dreiss
Experimenter: Dr Marcelo da Silva
Experimenter: Miss Li Qian
Experimenter: Mr Xiang Xu
Local Contact: Dr Gregory Smith

DOI: 10.5286/ISIS.E.RB2400073

ISIS Experiment Number: RB2400073

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Cecile Dreiss et al; (2024): Self-assembled polyrotaxane hydrogels based on dynamic disulfide bonds, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2400073

Data is released under the CC-BY-4.0 license.