ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Cartilage?inspired alginate LipoGels: Impact of different liposomes
Abstract: Inspired by the exceptional lubricity in living systems (e.g. knee joints), a physically cross-linked hydrogel has been prepared from sodium alginate, an abundant green biopolymer derived from brown algae. Alginate hydrogels were cross-linked by divalent cations, Ca2+, and liposomes (or lipid vesicles) were embedded into the gel (Fig. 1), aiming to generate a lubricious and self-repairing material, also with the potential for therapeutic inclusion. The lubrication performance of the alginate hydrogels was evaluated with a tribometer (UMT Tribolab), and the results showed that the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) embedded alginate hydrogel exhibited excellent lubrication with a coefficient of friction (CoF) of 0.022 under water. Furthermore, valuable structural information on the polymer network mesh size ? (Fig. 1) was obtained from a recent small angle neutron scattering (SANS) experiment at SANS2D. To complete a PhD study (in the 4th year), we propose a SANS investigation of the effect of different types of liposomes with varying headgroup charges and tail lengths/fluidity on the hydrogel structures. The results will offer structural insights into alginate hydrogels embedded with different types of liposomes, enabling a correlation with the mechanical characterisation of the hydrogels using nano-indenter and rheometer. Ultimately, this will underpin the rational design of robust hydrogels with tailored nanostructures for biomimetic lubrication.
Principal Investigator: Professor Wuge Briscoe
Experimenter: Miss Xueying Guo
Local Contact: Dr Diego Alba Venero
Experimenter: Dr Magdalena Wlodek
Experimenter: Miss Holly Stockdale
Experimenter: Mr Tao Ma
DOI: 10.5286/ISIS.E.RB2420077
ISIS Experiment Number: RB2420077
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2420077-1 | ZOOM | 04 December 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Wuge Briscoe et al; (2024): Cartilage?inspired alginate LipoGels: Impact of different liposomes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420077
Data is released under the CC-BY-4.0 license.
