ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
?-Synuclein Membrane Aggregation
Abstract: Parkinson?s disease is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the brain, resulting in motor deficits. Key to its pathology are Lewy bodies, aggregates of ?-Synuclein, pivotal for normal neuronal function but prone to forming pathogenic structures. Notably, ?-Synuclein undergoes conformational changes on cell membranes, contributing to its aggregation into toxic forms, a crucial event in disease progression. Understanding these interactions is vital for deciphering Parkinson's disease and developing therapies. Our proposal plans to use SANS to study the aggregation of a model lipid-?-Synuclein system, aiming to elucidate the nanostructures and understand the mechanisms and ways to inhibit this process. Additionally, our collaborator UCB is advancing Minzasolmin in phase 3 trials, targeting ?-Synuclein aggregation as a potential therapeutic avenue.
Principal Investigator: Dr Andrew Parnell
Local Contact: Dr James Doutch
Experimenter: Dr Rosemary Staniforth
Experimenter: Mr Alexander Arscott-Barber
Experimenter: Mr Calum Lloyd
DOI: 10.5286/ISIS.E.RB2420468
ISIS Experiment Number: RB2420468
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2420468-1 | SANS2D | 21 December 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Andrew Parnell et al; (2024): ?-Synuclein Membrane Aggregation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420468
Data is released under the CC-BY-4.0 license.
