ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Microscopic dynamics of brain lipids in a model membrane: Influence of phenylalanine
Abstract: Phenylketonuria (PKU), an inherited disorder, is mainly associated with the self-assembly of toxic fibrillar aggregates of phenylalanine (Phe) in blood at elevated concentrations. Present proposal aims to understand the effects of the Phe on the microscopic dynamics of lipids in unilamellar vesicles by using quasielastic neutron scattering (QENS). The vesicles will be prepared by brain extracted lipids to closely mimic the biological membrane. This QENS results along with the structural data from synchrotron X-ray scattering experiments may help to understand the molecular mechanism of suchdiseases.
Principal Investigator: Dr Sajal Kumar Ghosh
Experimenter: Ms Jyoti Gupta
Local Contact: Dr Victoria Garcia Sakai
Experimenter: Dr Prashant Hitaishi
Experimenter: Dr Veerendra K Sharma
DOI: 10.5286/ISIS.E.RB2368003
ISIS Experiment Number: RB2368003
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2368003-1 | IRIS | 03 August 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Sajal Kumar Ghosh et al; (2024): Microscopic dynamics of brain lipids in a model membrane: Influence of phenylalanine, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2368003
Data is released under the CC-BY-4.0 license.
