ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Lipid-based nanostructured drug carriers designed for Docetaxel delivery: Characterization using Inelastic Neutron Scattering
Abstract: Cancer is one of the leading causes of mortality worldwide, accounting for one in six deaths. This disease affects individuals of all ages and ethnic backgrounds, presenting a significant challenge to global public health. The main antineoplastic agents, such as docetaxel (DTX) used in the treatment of lung and breast cancer, have limitations such as low water solubility, tissue toxicity and rapid degradation. Such challenges can be overcome with the use of nanocarriers, as in the case of nanostructured lipid carriers (NLC) [1,2]. This compound is a promising contribution by nanotechnology in pharmaceutical sciences increasing the bioavailability [2,3]. We developed a nanostructured hybrid system composed of NLC incorporating docetaxel (DTX, 0.5%) adsorbed on a biopolymeric matrix of xanthan-chitosan gum (3:1%). Our objective in this proposal is to study the structural organization of lipid-based drug delivery systems: NLC composed of Myristyl Myristate (SL) and Miglyol 812 (LL) in two different concentrations containing DTX and the surfactant Pluronic F58, in addition to Copaiba Oil.
Principal Investigator: Dr Fabiano Yokaichiya
Experimenter: Dr Katia Oliveira
Experimenter: Dr Leide Cavalcanti
Experimenter: Mr Rodrigo Rhinow
Local Contact: Dr Svemir Rudic
Experimenter: Dr Margareth K.K.D. Franco
Experimenter: Ms Thais Oliveira
Experimenter: Mr Lucas Battiston
Experimenter: Professor Cicero Avila-Neto
DOI: 10.5286/ISIS.E.RB2410138
ISIS Experiment Number: RB2410138
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2410138-1 | TOSCA | 07 August 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Fabiano Yokaichiya et al; (2024): Lipid-based nanostructured drug carriers designed for Docetaxel delivery: Characterization using Inelastic Neutron Scattering, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2410138
Data is released under the CC-BY-4.0 license.
