ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Unravelling Microscopic Dynamics and Phase behaviour of Lipoplexes
Abstract: Gene therapy is a novel medical approach that aims to treat and prevent diseases by manipulating the expression of genes. Efficient and safe delivery of genes into appropriate cells is a crucial part of gene therapy. Cationic liposomes have shown great promise as nonviral carriers of gene. A synthetic cationic lipid, dioctadecyldimethylammonium bromide (DODAB) is touted as one such candidate, which has demonstrated efficiency in gene/DNA transfection. DODAB forms complexes with DNA referred to as lipoplexes. The kinetics of gene delivery is substantially controlled by the microscopic dynamics of these lipoplexes. The aim of current proposal is to investigate the phase behaviour and the associated microscopic dynamics of DODAB-DNA lipoplexes using quasielastic neutron scattering and elastic fixed window scans.
Principal Investigator: Dr Veerendra K Sharma
Experimenter: Dr Subhankur Mitra
Experimenter: Ms Jyoti Gupta
Local Contact: Dr Victoria Garcia Sakai
Experimenter: Mr Harish Srinivasan
DOI: 10.5286/ISIS.E.RB2310290
ISIS Experiment Number: RB2310290
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2310290-1 | IRIS | 24 July 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Veerendra K Sharma et al; (2024): Unravelling Microscopic Dynamics and Phase behaviour of Lipoplexes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310290
Data is released under the CC-BY-4.0 license.
