ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Understanding the organization of phenylalanine in and around a model cellular membrane
Abstract: Phenylalanine (Phe) is one of the essential amino acids that act as a precursor for the synthesis of various neurotransmitters. Imbalance of these molecules causes many diseases (e.g. Phenylketonuria, Alzheimer?, etc) which are mainly associated with the self-assembly of toxic fibrillar aggregates of Phe around the brain membrane. It is important to investigate effects of such Phe fibrillar aggregates on the cell membrane to understand the mechanism of their adverse actions. Present study will provide a molecular level description of this assembly in the model brain membrane which will be quantified by the neutron reflectivity.
Principal Investigator: Dr Veerendra K Sharma
Experimenter: Dr Luke Clifton
Experimenter: Dr Prashant Hitaishi
Local Contact: Dr Mario Campana
Experimenter: Dr Sajal Kumar Ghosh
DOI: 10.5286/ISIS.E.RB2310312
ISIS Experiment Number: RB2310312
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2310312-1 | SURF | 25 July 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Veerendra K Sharma et al; (2024): Understanding the organization of phenylalanine in and around a model cellular membrane, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310312
Data is released under the CC-BY-4.0 license.
