ISIS Neutron and Muon Source Data Journal

Neutron Reflection Studies for the Sphingosine Phosphate (S1P) interaction with Model Lipid Membranes

Abstract: Sphingolipids are the important components of eukaryotic cell membranes, and play many biological roles in signal transduction, cell adhesion, and neuron myelinization. Two important sphingolipids, sphingosine (Sph) and its phosphorylated form S1P, work as signal molecules to regulate cell fate at cell membrane. The variation of membrane structure after incorporating Sph or S1P, and the distribution and the location of sphingosine in membrane are the key to understand the unique role of sphingosine in the variation of membrane permeability and even the cell death. Using the deuterium labelling, Neutron reflectivity enables us to investigate Sphingolipids interaction with model membrane at molecular level, which will relate directly to the nature of interaction and how it affects cellular function.

Principal Investigator: Dr Peixun Li
Experimenter: Mr Yonghang Mu
Experimenter: Dr Luke Clifton
Experimenter: Professor Jeffery Penfold
Experimenter: Dr Kun Ma
Local Contact: Dr Stephen Hall
Experimenter: Dr John Webster
Experimenter: Dr Yao Chen
Experimenter: Dr Zi Wang

DOI: 10.5286/ISIS.E.RB2410669

ISIS Experiment Number: RB2410669

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Peixun Li et al; (2024): Neutron Reflection Studies for the Sphingosine Phosphate (S1P) interaction with Model Lipid Membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2410669

Data is released under the CC-BY-4.0 license.