ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Interactions between nano-ions and a lipid monolayer: Nano-structural insights from NR
Abstract: Nano-ions have recently attracted increasing interest due to their fascinating properties. Nano-ions such as polyoxometalates (POMs), boron clusters and hydrophobic ions, are nanometric ionic molecules with unique architecture and super-chaotropic properties. They have promising antitumor, anti-infectious and anti-Alzheimer?s activities. Despite nano-ions promising membrane-targeting ability, direct evidence for the proposed mechanism based on the formation and desorption of POM-lipid assemblies is lacking. Their interactions with cell membranes, relevant to their cytotoxicity and drug delivery applications, remain poorly understood. Our recent trial results from XRR experiment at ESRF BM28 showed that mixed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/ 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) vesicles ruptured on mica surface to form lipid bilayers (SLBs). The Kiessig fringes of SLBs become more pronounced with increasing temperature. The addition of nano-ions to SLBs resulted in structural changes, which depend on the type of the nano-ion used. Here, we propose a complementary neutron reflectivity (NR) study of the effects of nano-ions on the lipid monolayer at the air-water interface on an LB trough, as a function of lipid composition, type of nano-ions, concentrations, surface pressure, and temperature.
Principal Investigator: Professor Wuge Briscoe
Local Contact: Dr Rebecca Welbourn
Experimenter: Miss Charlotte Kenton
Experimenter: Mr Oliver McDowell
Experimenter: Dr Magdalena Wlodek
Experimenter: Dr Maxmilian Skoda
Experimenter: Mr Matteo Fois
Experimenter: Miss Xueying Guo
Experimenter: Miss Sofia Rogers Ruiz
DOI: 10.5286/ISIS.E.RB2320226
ISIS Experiment Number: RB2320226
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2320226-1 | INTER | 22 March 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Wuge Briscoe et al; (2024): Interactions between nano-ions and a lipid monolayer: Nano-structural insights from NR, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2320226
Data is released under the CC-BY-4.0 license.
