ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
The lipid-based nanostructured drug carriers designed for the Docetaxel delivery
Abstract: Cancer is one of the leading causes of mortality worldwide, accounting for one in six deaths. In Brazil, non-melanoma skin cancer is the most prevalent, responsible for approximately 185,000 new cases each year. The main antineoplastic agents, such as docetaxel (DTX) have limitations such as low water solubility, tissue toxicity and rapid degradation. Such challenges can be overcome with the use of nanocarriers, as in the case of nanostructured lipid carriers (NLC). This compound is a promising contribution by nanotechnology in pharmaceutical sciences. The applicability of NLC in drug delivery allows increasing the bioavailability of pharmacological active compounds [3,4]. We developed a nanostructured hybrid system composed of NLC incorporating docetaxel (DTX, 0.5%) adsorbed on a biopolymeric matrix of xanthan-chitosan gum (3:1%). Through this formulation, an innovative drug delivery system for the treatment of skin cancer is proposed to release DTX. Our objective in this proposal is to study the structural organization of lipid-based drug delivery systems: NLC composed of Myristyl Myristate (SL) and Miglyol 812 (LL) in two different concentrations containing DTX and the surfactant Pluronic F58, in addition to Copaiba Oil. To this end, we are submitting this proposal to measure our samples at SANS2d beamtime, which will be very important for characterizing our drug delivery system.
Principal Investigator: Ms Thais Oliveira
Experimenter: Dr Margareth K.K.D. Franco
Local Contact: Dr Leide Cavalcanti
Experimenter: Dr Fabiano Yokaichiya
Experimenter: Professor Guinther Kellermann
DOI: 10.5286/ISIS.E.RB2410156
ISIS Experiment Number: RB2410156
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2410156-1 | SANS2D | 09 March 2027 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Ms Thais Oliveira et al; (2024): The lipid-based nanostructured drug carriers designed for the Docetaxel delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2410156
Data is released under the CC-BY-4.0 license.
