ISIS Neutron and Muon Source Data Journal

A follow-up of RB2220594: Probing the effects of shear and extension on Nanodrug Hydrogel Drug Systems using Rheo-SANS

Abstract: The proposed experiments are a follow-up for beamtime RB2220594, aiming to evaluate and optimise a novel smart controlled release injectable liposomal hydrogel drug delivery system from low cost precursors, Pluronic F-127 and Chitosan. The matrix?s sol-gel phase transition in the body allows them to be administered as drug loaded solutions before transforming to soft gel depots at body temperature, then releasing the drug over a designed time. The liposomes? structural similarity to cells allows for enhanced drugs bioavailability and increased blood circulation time. The proposed systems are designed to regulate the release of Secukinumab® for the treatment of plaque Psoriasis, aiming to reduce cost/dosing frequency and enhance patients? compliance. The requested beamtime will build on the previous successful experiments using three bespoke flow cells, to optimise data collection, expand measurements in both x and y axes and map structural progression in both shear and extension, as experienced during processing and real bodily administration. Paired with previously published work and ongoing rheological/optical measurements the beamtime will allow full understanding of the flow-structure correlation, instability dynamics in soft matter, and create a model for release behaviour from systems with similar morphology.

Principal Investigator: Dr Bana Shriky
Experimenter: Dr Maksims Babenko
Local Contact: Dr Najet Mahmoudi
Experimenter: Professor Tim Gough

DOI: 10.5286/ISIS.E.RB2320210

ISIS Experiment Number: RB2320210

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Bana Shriky et al; (2024): A follow-up of RB2220594: Probing the effects of shear and extension on Nanodrug Hydrogel Drug Systems using Rheo-SANS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2320210

Data is released under the CC-BY-4.0 license.