ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Investigation of the impact of polymer brush hydrophobicity and conformational rigidity on oligonucleotide uptake
Abstract: Gene therapy has potential in treating diseases, but challenges remain in improving stability and efficacy of vectors. Polycationic brushes on nanoparticles have shown promise in capturing genetic material with high transfection efficiencies. This proposal aims to investigate the architecture of complexes formed by RNA and mRNA with dense brushes made of various polymers to identify the optimal brush chemistry and architecture for delivering different types of RNA molecules.
Experimenter: Dr Ali Zarbakhsh
Experimenter: Professor Julien Gautrot
Local Contact: Dr Mario Campana
DOI: 10.5286/ISIS.E.RB2320023
ISIS Experiment Number: RB2320023
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2320023-1 | OFFSPEC | 15 December 2026 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Ali Zarbakhsh et al; (2023): Investigation of the impact of polymer brush hydrophobicity and conformational rigidity on oligonucleotide uptake, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2320023
Data is released under the CC-BY-4.0 license.
