ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
How Does Hydrophobicity Change of Nonionic Surfactant Influence the Co-adsorption of Monoclonal Antibody and Surfactant at the Amphiphilic Self-assembled Interface?
Abstract: We have previously found that nonionic surfactants, such as Polysorbate 80 (commonly denoted as PS80 or Tween 80), could form a monolayer on amphiphilic UV-TMOS treated surface, greatly inhibiting mAb from further adsorption. We speculate that the hydrophilic heads of PS80, which are adsorbed on the outside of the UV-TMOS interface, prevent further adsorption of the mAbs. This aroused our interest to investigate whether the hydrophobicity of surfactants, especially headgroup size, would impact the co-adsorption of mAb and surfactant.
Principal Investigator: Professor Jian Lu
Local Contact: Dr Oleksandr Tomchuk
Experimenter: Mr kangcheng shen
Experimenter: Mr Zeyuan ZHUANG
Experimenter: Miss Tianhao Ge
DOI: 10.5286/ISIS.E.RB2320042
ISIS Experiment Number: RB2320042
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2320042-1 | OFFSPEC | 19 December 2026 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2023): How Does Hydrophobicity Change of Nonionic Surfactant Influence the Co-adsorption of Monoclonal Antibody and Surfactant at the Amphiphilic Self-assembled Interface?, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2320042
Data is released under the CC-BY-4.0 license.
