ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Simultaneous loading of miltefosine and pentamidine in micelles and micellar gels of poloxamines for the treatment of leishmaniasis
Abstract: Leishmaniasis (LS) is a neglected tropical disease (NTD) with high morbidity and mortality, considered the second leading cause of death worldwide by a parasitic agent after malaria. The available drugs against LS exhibit high toxicity and long duration schedules that can be overcome with more efficient formulations. Tetronic®, a family of block copolymers with temperature and pH-responsiveness, can encapsulate miltefosine, a phospholipid with activity against various parasite species, as well as pentamidine, used to treat LS. Our objective in this proposal is to elucidate by SANS the structures formed by Tetronic aggregates loaded with both drugs under physiological conditions. The experiments will be conducted at the diluted (micelles) and concentrated regimes (gels, intended for topical application in cutaneous LS). The ultimate goal is the design of formulations for the treatment of NTDs based on dual combination therapy, in which the drugs act at lower concentrations, thus reducing the side effects while keeping their therapeutic action. This proposal is a continuation of RB2210097 experiment.
Local Contact: Dr Gregory Smith
Experimenter: Miss Zeinab Dirany
Experimenter: Mr Javier Carriles
Experimenter: Professor Gustavo Gonzalez-Gaitano
DOI: 10.5286/ISIS.E.RB2310301
ISIS Experiment Number: RB2310301
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2310301-1 | LARMOR | 18 December 2026 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Gregory Smith et al; (2023): Simultaneous loading of miltefosine and pentamidine in micelles and micellar gels of poloxamines for the treatment of leishmaniasis, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310301
Data is released under the CC-BY-4.0 license.
