ISIS Neutron and Muon Source Data Journal

Microstructure of poly-L-lysine (PLL) single chain nanoparticles: The role of the precursor conformation

Abstract: Polypeptide single chain nanoparticles (SCNPs) have enormous potential in biomedical applications due to their biocompatibility and low immunogenicity. Among the homo-polypeptides, polylyisine has established applications on gene delivery that would benefit from the morphology provided by SCNPs. However, it is challenging to form SCNPs from a weak polyelectrolyte because its rigidity prevents chain collapse upon cross-linking. Thus, it is important to understand the role of the initial linear chain conformation on the resulting SCNP morphology. This proposal aims to use SANS to probe the effect of the poly-L-lysine (PLL) conformation through solvent conditions on the morphology of the resulting SCNPs.

Local Contact: Dr Leide Cavalcanti
Experimenter: Ms Thu Phuong LE
Experimenter: Dr Paula Malo de Molina
Experimenter: Professor Arantxa Arbe

DOI: 10.5286/ISIS.E.RB2320115

ISIS Experiment Number: RB2320115

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Leide Cavalcanti et al; (2023): Microstructure of poly-L-lysine (PLL) single chain nanoparticles: The role of the precursor conformation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2320115

Data is released under the CC-BY-4.0 license.